Publications by authors named "F J Sakai"
Sialyl glycans have several biological functions. We have previously reported on the preparation and bifidogenic activity of milk-derived sialylglycopeptide (MSGP) concentrate containing sialyl -glycans. The current study qualitatively and quantitatively analyzed the sialyl -glycans present in the MSGP concentrate.
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- - The study aimed to assess how common lung cancer is among patients with rheumatoid arthritis (RA) and identify factors that predict its occurrence.
- - Out of 771 RA patients followed for an average of 9.3 years, different lung conditions showed varied lung cancer incidence rates, with CPFE patients at the highest risk (47.8 cases per 1,000 patient-years).
- - Findings suggest that RA patients with smoking history and pulmonary complications, particularly CPFE, should be closely monitored for lung cancer risk.
Background: Few studies of migraine have evaluated migraine disability across multiple countries using the same methodology.
Methods: This cross-sectional, web-based survey was conducted in 2021-2022 in Canada, France, Germany, Japan, UK and USA. Respondents with migraine were identified based on modified International Classification of Headache Disorders, 3rd edition, criteria.
Aims: To investigate the molecular events associated with acquiring macrolide resistance genes [mefE/mel (Mega) or ermB] in Streptococcus pneumoniae (Spn) during nasopharyngeal colonization.
Methods And Results: Genomic analysis of 128 macrolide-resistant Spn isolates revealed recombination events in genes of the conjugation apparatus, or the competence system, in strains carrying Tn916-related elements. Studies using confocal and electron microscopy demonstrated that during the transfer of Tn916-related elements in nasopharyngeal cell biofilms, pneumococcal strains formed clusters facilitating their acquisition of resistance determinants at a high recombination frequency (rF).
Objective: To assess rates of traversing barriers to care to access optimal clinical outcomes in people with migraine internationally.
Background: People in need of medical care for migraine should consult a health care professional knowledgeable in migraine management, obtain an accurate diagnosis, and receive an individualized treatment plan, which includes scientific society guideline-recommended treatments where appropriate.
Methods: The Chronic Migraine Epidemiology and Outcomes-International (CaMEO-I) Study was a cross-sectional, web-based survey conducted from July 2021 through March 2022 in Canada, France, Germany, Japan, the United Kingdom, and the United States (US).