Publications by authors named "F J PERERA"
Introduction: Air pollution poses serious health risks to humans, with particular harm to children.
Objectives: To address the gap in understanding the efficacy of policies to reduce exposure to air pollution, we sought to assess the temporal relationship between the enactment of major air pollution and climate policies in NYC and trends in air quality during the period 1998-2021. We used previously available data from citywide monitoring and new data from the Columbia Center for Children's Environmental Health (CCCEH) longitudinal cohort studies of mothers and children living in communities in Northern Manhattan and the South Bronx.
Background: A large body of data shows that fetal brain development is vulnerable to disruption by air pollution experienced by the mother during pregnancy, adversely affecting cognitive and psychomotor capabilities during childhood (De Asis-Cruz et al., Biol Psychiatry 7:480-90, 2022; Morgan ZEM et al., Environ Health 22:11, 2023).
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- Low mtDNA copy number (mtDNAcn) in early life has been linked to cognitive decline, but its impact on healthy cognitive development in children is still unclear.
- The study measured mtDNAcn in umbilical cord blood and child blood at ages 5-7 and analyzed cognitive performance later using standardized tests, finding that both low and high mtDNAcn were associated with poorer cognitive outcomes.
- Results suggest mtDNAcn may be an important biomarker for assessing neurocognitive performance in children, highlighting the need for further research on mitochondrial markers in healthy populations.
Article Synopsis
- The study was about a treatment for breast cancer that used a type of radiation called partial breast irradiation (PBI), which was given once a day for a week.
- They wanted to see if two different doses of radiation (30 Gy and 27.5 Gy) would have good effects on how patients' breasts looked two years later.
- The results showed that both doses had acceptable cosmetic outcomes, but they decided to use the lower dose (27.5 Gy) for the next phase of the trial.