Publications by authors named "F J O'Neill"
Sediment penetration by towed, seabed-contacting, fishing gear components.
Mar Pollut Bull
December 2024
The penetration of towed fishing gears into the seabed is directly related to contact drag, fuel consumption, habitat alteration and to the depletion of benthic fauna. Hence, is an important parameter in relation to the environmental and ecological impact of towed demersal fishing gears. Here, we use a benthic sledge to tow bottom contacting gear components across soft sediment substrates and make high resolution measurements of their penetration, while the impact is taking place.
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- A study was conducted on ceramic-on-metal hip replacements originally performed from 2007 to 2009 to assess their long-term outcomes after 5.8 and 10.1 years.
- The revision rates increased from 3.1% at six years to 8.8% at ten years, with a notable rise in pain scores and decline in overall hip function during that time.
- The findings revealed significant issues like increased radiolucent lines in X-rays and higher metal ion levels, indicating that the survival rate for these implants dropped to 91.2%, below the recommended threshold, raising concerns for future implant designs.
Article Synopsis
- Marine sediments are significant carbon stores, but bottom trawl fisheries disturb seabed habitats, potentially impacting the ocean's carbon dioxide sink.
- Research is concerned that trawling may turn these sediments into a significant source of CO, but there's a lot of uncertainty due to limited understanding of how trawling affects sediment mixing and carbon processes.
- A review protocol will investigate the effects of mobile bottom fishing on carbon processing and storage in sediments by addressing various questions about carbon types, fluxes between benthic and pelagic systems, and the biological and physical controls on this carbon.
Background: HER2-targeted therapies have revolutionised the treatment of HER2-positive breast cancer. However, de novo resistance or the emergence of acquired resistance is a persistent clinical problem. Here we report that neratinib, an irreversible pan-HER inhibitor, in combination with the multi-kinase inhibitor dasatinib, currently used to treat certain leukemias, has strong anti-proliferative effects against models of HER2-positive breast cancer that are innately resistant to trastuzumab or have acquired resistance to neratinib.
View Article and Find Full Text PDFBackground: This systematic literature review compares the clinical outcomes of heparin-bonded expanded polytetrafluoroethylene with autologous saphenous vein in the management of patients undergoing below-the-knee bypass to treat peripheral arterial disease.
Methods: An electronic literature search was conducted in MEDLINE and Embase to identify comparative studies in patients who underwent below-the-knee surgical bypass. Studies were screened at abstract and full text review using predefined inclusion criteria by two independent reviewers and critically appraised for risk of bias.