Publications by authors named "F J Nobrega"
Article Synopsis
- Bacteria can host foreign genetic elements like plasmids and bacteriophages, which were once thought to be separate but now show significant interaction.
- Phage-plasmids (P-Ps) have unique functions, acting as both plasmids that exist independently and phages that can infect and destroy bacteria, allowing for the spread of genetic traits such as antibiotic resistance.
- The review highlights the need for more research on the ecological roles and prevalence of P-Ps in microbial communities, despite existing studies on their characteristics and functions.
Pangenome graphs can represent all variation between multiple reference genomes, but current approaches to build them exclude complex sequences or are based upon a single reference. In response, we developed the PanGenome Graph Builder, a pipeline for constructing pangenome graphs without bias or exclusion. The PanGenome Graph Builder uses all-to-all alignments to build a variation graph in which we can identify variation, measure conservation, detect recombination events and infer phylogenetic relationships.
View Article and Find Full Text PDFArticle Synopsis
- * L. paracasei successfully produced bioemulsifiers when cultured under specific conditions, but the culture supernatants did not show antioxidant activity, though they did have some antidiabetic and lipolytic activities.
- * The production of bacteriocins was positively influenced by the concentration of peptone and lactose as well as pH levels, indicating that L. paracasei has potential applications in pharmaceuticals, cosmetics, environmental solutions, food, and biomedical fields. *
Understanding the dynamic evolution of Salmonella is vital for effective bacterial infection management. This study explores the role of the flexible genome, organised in regions of genomic plasticity (RGP), in shaping the pathogenicity of Salmonella lineages. Through comprehensive genomic analysis of 12,244 Salmonella spp.
View Article and Find Full Text PDFEnterotoxigenic (ETEC) is a diverse and poorly characterized pathotype that causes diarrhea in humans and animals. Phages have been proposed for the veterinary biocontrol of ETEC, but effective solutions require understanding of porcine ETEC diversity that affects phage infection. Here, we sequenced and analyzed the genomes of the PHAGEBio ETEC collection, gathering 79 diverse ETEC strains isolated from European pigs with post-weaning diarrhea (PWD).
View Article and Find Full Text PDF