Publications by authors named "F J McGuigan"
Article Synopsis
- The study aimed to compare bone mineral density (BMD) and osteoporosis rates in systemic sclerosis (SSc) patients to those in a general population, highlighting specific SSc-related factors influencing BMD.
- It involved 211 SSc patients (majority women) and 505 control participants, measuring BMD at the hip and lumbar spine using X-ray technology, with specific criteria for osteopenia and osteoporosis.
- Results showed significantly lower BMD in SSc patients, particularly women, with factors like age, BMI, menopause, and certain SSc symptoms (like finger ulcers) contributing to decreased BMD, highlighting the need for bone health evaluations in all SSc patients.
Osteosarcopenia is the coexistence of low bone mass and sarcopenia. In older women, its prevalence is not well described, and it is unknown if sarcopenia is additive to low bone mass for fracture and mortality risk. The study investigated prevalence of osteosarcopenia and if osteosarcopenia is associated with higher fracture and mortality risk than low bone mass alone in older community-dwelling women.
View Article and Find Full Text PDFArticle Synopsis
- A meta-analysis of data from 46 cohorts found that individuals who reported falling in the past year had an increased risk of fractures, highlighting falls as an important factor for fracture risk assessment.
- Previous falls were correlated with a significant rise in fracture risks for both men and women, with hazard ratios indicating that the risk is greater for men.
- The study suggests that falls should be included in the FRAX® algorithm, which currently does not consider this important risk factor for osteoporotic fractures.
Objective: The class II transactivator (CIITA), encoded by the CIITA gene, controls expression of immune response regulators, which affect bone homeostasis. Previously, we investigated a functional CIITA polymorphism in elderly women. Women carrying the allele associated with lower CIITA levels displayed higher bone mineral density (BMD), but also higher bone loss.
View Article and Find Full Text PDF