Publications by authors named "F J Ferrandino"
Malignant transformation of T-cell progenitors causes T-cell acute lymphoblastic leukemia (T-ALL), an aggressive childhood lymphoproliferative disorder. Activating mutations of Notch, Notch1 and Notch3, have been detected in T-ALL patients. In this study, we aimed to deeply characterize hyperactive Notch3-related pathways involved in T-cell dynamics within the thymus and bone marrow to propose these processes as an important step in facilitating the progression of T-ALL.
View Article and Find Full Text PDFMosquitoes were collected for 12 consecutive months beginning June 2016, from 11 locations in the Florida Everglades, Collier County, and tested for viruses by isolation in Vero cells and subsequent identification. One species complex and 31 species of mosquitoes were identified from 668,809 specimens. Ochlerotatus taeniorhynchus comprised 72.
View Article and Find Full Text PDFArticle Synopsis
- West Nile virus was first identified in the U.S. in 1999, isolated from specific mosquito species Culex pipiens pipiens and Aedes vexans.
- A Connecticut strain of Ae. vexans was shown to effectively transmit the virus both to suckling mice and to its offspring in laboratory settings.
- Transmission rates increased over time, with high horizontal transmission rates observed by days 28-30 post-exposure, while vertical transmission was noted after the mosquito's third bloodmeal, potentially helping the virus survive winter.