Publications by authors named "F J Diez-Guerra"
The coordination of neuronal wiring and activity within the central nervous system (CNS) is crucial for cognitive function, particularly in the context of aging and neurological disorders. Neurogranin (Ng), an abundant forebrain protein, modulates calmodulin (CaM) activity and deeply influences synaptic plasticity and neuronal processing. This study investigates the regulatory mechanisms of Ng expression, a critical but underexplored area for combating cognitive impairment.
View Article and Find Full Text PDFNeurogranin (Ng) is a calmodulin (CaM)-binding protein that is phosphorylated by protein kinase C (PKC) and is highly enriched in the dendrites and spines of telencephalic neurons. It is proposed to be involved in regulating CaM availability in the post-synaptic environment to modulate the efficiency of excitatory synaptic transmission. There is a close relationship between Ng and cognitive performance; its expression peaks in the forebrain coinciding with maximum synaptogenic activity, and it is reduced in several conditions of impaired cognition.
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- Na1.5 and Kir2.1 channels in heart muscle cells form dynamic complexes that may travel together to specific membrane regions during their development.
- Experiments showed that when these channels were coexpressed, they affected each other's surface expression and mobility, indicating early association in their production process.
- The study highlighted the role of an adaptor protein, AP1, in the trafficking and functioning of Na1.5 and Kir2.1, suggesting that it may help incorporate these channels into cellular structures necessary for proper heart function.
Cardiac Kir2.1 and Nav1.5 channels generate the inward rectifier K (I) and the Na (I) currents, respectively.
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