Accurate consistency-based MSA reducing the memory footprint.

Background And Objective: The emergence of Next-Generation sequencing has created a push for faster and more accurate multiple sequence alignment tools. The growing number of sequences and their longer sizes, which require the use of increased system resources and produce less accurate results, are heavily challenging to these applications. Consistency-based methods have the most intensive CPU and memory usage requirements.

Neurological presentations of Bartonella henselae infection.

Objective: Neurological symptoms in patients with cat-scratch disease (CSD) have been rarely reported. The aim of this study is to analyze the frequency of neurological CSD (NCSD) and describe the disease clinical presentation, management and outcome.

Material And Methods: We retrospectively selected patients with a CSD syndrome and Bartonella IgG titers > 1:256.

Scalable Consistency in T-Coffee Through Apache Spark and Cassandra Database.

Next-generation sequencing, also known as high-throughput sequencing, has increased the volume of genetic data processed by sequencers. In the bioinformatic scientific area, highly rated multiple sequence alignment tools, such as MAFFT, ProbCons, and T-Coffee (TC), use the probabilistic consistency as a prior step to the progressive alignment stage to improve the final accuracy. However, such methods are severely limited by the memory required to store the consistency information.

A curious fact: Photic sneeze reflex. Autosomical dominant compelling helio-ophthalmic outburst syndrome.

Objective: To assess ocular involvement in the pathophysiology of autosomal dominant compelling helio-ophthalmic outburst syndrome (ACHOOs).

Methods: An interview was conducted with a Caucasian family that showed clinical features of ACHOOs. Twelve of them had photic reflex and were recruited.

Foster Kennedy Syndrome: An Atypical Presentation.

Purpose: To describe an unusual presentation of Foster Kennedy syndrome (FKS; unilateral optic nerve atrophy with optic nerve edema in the other eye) with optic nerve atrophy and retinal vein occlusion. It is an example of how common clinical features can hide a rare condition or presentation of a disease. Foster Kennedy syndrome is uncommon.