Publications by authors named "F J Chicano Marin"

Background: Lynch syndrome (LS), characterised by an increased risk for cancer, is mainly caused by germline pathogenic variants affecting a mismatch repair gene (MLH1, MSH2, MSH6, PMS2). Occasionally, LS may be caused by constitutional MLH1 epimutation (CME) characterised by soma-wide methylation of one allele of the MLH1 promoter. Most of these are "primary" epimutations, arising de novo without any apparent underlying cis-genetic cause, and are reversible between generations.

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Background: Heart failure (HF) often occurs in patients with atrial fibrillation (AF), with a major impact on prognosis. Few data are available on the effect of integrated treatment strategies to improve prognosis in patients with AF. We aimed to evaluate the association between HF (according to left ventricular ejection fraction [LVEF]), HF optimal medical therapy and adherence to the Atrial Fibrillation Better Care pathway, and major outcomes in patients with AF.

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The paper manufacturing process produces liquid and gaseous alternative fuels, as well as solid wastes. These can be subsequently treated through chemical processing, oxidation, and thermal activation, resulting in adsorbent materials with CO adsorption capacities. The valorisation of black liquor waste resulting from paper manufacturing was achieved through a catalytic pyrolysis process using two catalysts previously prepared in house (Cu-Zn-MCM-41 and Ni-SBA-16).

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Objective: To assess the prognostic impact of a routine invasive strategy according to the frailty burden in patients with non-ST-segment elevation myocardial infarction (NSTEMI) from the MOSCA-FRAIL clinical trial.

Methods: The MOSCA-FRAIL trial randomized 167 frail patients, defined by a Clinical Frailty Scale (CFS) ≥ 4, with NSTEMI to an invasive or conservative strategy. The primary endpoint was the number of days alive and out of hospital (DAOH) one year after discharge.

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Article Synopsis
  • A study was conducted on atrial fibrillation (AF) patients starting vitamin K antagonist (VKA) therapy to determine the effect of comorbidities, frailty, and malnutrition on clinical outcomes.
  • The research found that a majority of patients had multiple health issues, and frailty significantly increased the risks for major bleeding and death, while malnutrition heightened the risk for strokes and overall mortality.
  • These findings underline the importance of addressing these factors in AF patients to improve their health outcomes during VKA treatment.
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