Publications by authors named "F J Bradley"
Implementing targeted vaccination activities to address inequalities in vaccination: a qualitative study.
J Public Health (Oxf)
January 2025
Background: As the UK COVID-19 vaccination programme progressed, greater emphasis was placed on the implementation of localized targeted vaccination activities to address inequalities in vaccination coverage. This study examines one UK region's approach to the delivery of targeted vaccination activities and identifies key factors influencing implementation.
Methods: Qualitative interviews were conducted with a purposive sample of key individuals involved in vaccination delivery across Greater Manchester (GM).
The injectable contraceptive, depot medroxyprogesterone acetate (DMPA), is associated with compromised cervical mucosal barriers. High-resolution spatial transcriptomics is applied here to reveal the spatial localization of these altered molecular markers. Ectocervical tissue samples from Kenyan sex workers using DMPA, or non-hormonal contraceptives, underwent spatial transcriptomics and gene set enrichment analyses.
View Article and Find Full Text PDFChronic systemic immune activation significantly influences human immunodeficiency virus (HIV) disease progression. Despite evidence of a pro-inflammatory environment in the genital tract of HIV-infected women, comprehensive investigations into cervical tissue from this region remain limited. Similarly, the consequences of chronic HIV infection on the integrity of the female genital epithelium are poorly understood, despite its importance in HIV transmission and replication.
View Article and Find Full Text PDFArticle Synopsis
- A study was conducted to compare infantile hemangiomas (IH) in preterm infants versus term infants, focusing on their clinical features and risks of scarring.
- Results showed that preterm infants had a higher incidence of thicker and more irregular IH than term infants, with the severity correlating with how premature they were.
- The study had limitations, including its retrospective design and potential bias from only including patients from specialized centers, indicating that findings may not apply to all cases.
Article Synopsis
- The cervicovaginal epithelial barrier is vital for protecting the female reproductive tract from sexually transmitted infections, and its function is influenced by hormones like estradiol and progesterone.
- A study involved collecting mucosal and blood samples from Kenyan female sex workers, analyzing them at different menstrual cycle phases to assess the hormones' impact on gene and protein expression in the ectocervical mucosa.
- Findings indicated that during the follicular phase, higher estradiol levels were linked to better epithelial structure and increased barrier integrity, but there were no significant correlations involving progesterone or during the luteal phase.