Publications by authors named "F J Bosso"
Six flavonoids were identified and isolated from the ethanolic extract of Alternanthera tenella Colla (Amaranthaceae) whole plant (EEAT) including 2″-O-β-D-glucopyranosyl-vitexin (A19). Flavonoids have anti-inflammatory activity; however, the 2″-O-β-D-glucopyranosyl-vitexin anti-inflammatory property was not totally explored. The aim of the present study was to investigate the anti-inflammatory effects of ethanolic extract from A.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to identify the epidemiological profile and key factors influencing morbidity and mortality in high-risk noncardiac surgical patients in Brazil.
- Conducted as a multicenter observational research, it tracked 904 noncardiac surgical patients in intensive care units over 7 days, noting complication and mortality rates.
- Results showed a 29.9% complication rate and a 9.6% mortality rate within 28 days post-surgery, with higher risk factors including worse scores on the SAPS 3 and SOFA, longer surgical durations, and the nature of surgeries being emergencies.
Role of angiotensin II in sympathetic nervous system induced left ventricular dysfunction.
Can J Physiol Pharmacol
October 1999
Experiments were undertaken to determine whether angiotensin (Ang) II concentration increases during massive sympathetic nervous system (SNS) activation and whether such an increase plays a role in the pathogenesis of SNS-induced left ventricular (LV) dysfunction. We also sought to determine whether excessive Ca2+ uptake through L-type channels due to intense adrenoceptor activation is responsible for the LV dysfunction. AngII concentration was measured in the plasma and myocardium before and after massively activating the SNS with an intracisternal injection of veratrine.
View Article and Find Full Text PDFTime-dependent changes in norepinephrine-induced left ventricular dysfunction and histopathologic condition.
J Heart Lung Transplant
October 1998
Background: Intense activation of the sympathetic nervous system or administration of high concentrations of catecholamines diminishes myocardial contractility and produces infarct-like lesions throughout the heart. This study was conducted to determine whether norepinephrine-induced left ventricular (LV) dysfunction reverses with time and whether the histopathologic condition and the cardiac dysfunction produced by high doses of norepinephrine are causally related.
Methods: Norepinephrine, 10 microg bolus followed by 2.