Publications by authors named "F J Bikker"
Background: identification and removal of advanced adenomas (AA) reduce colorectal cancer (CRC) incidence and potentially mortality. CRC screening often uses fecal immunochemical testing to select high-risk individuals for colonoscopy, despite its low sensitivity for AA and relatively high false-positivity rate. Previous studies have linked proteases to CRC development through their ability to facilitate angiogenesis and immunoregulation.
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- Acute skin injuries compromise the skin barrier, increasing the risk of infections; Histatin 1 (Hst1) aids in wound healing by promoting cell adhesion and migration.
- However, Hst1 is rapidly degraded in wound exudates, whereas Cyclized hst1 (Cyclic-hst1) is more stable and resistant to protease degradation.
- Synthesized through a click reaction, Cyclic-hst1 demonstrated superior wound healing properties at significantly lower concentrations than Hst1, showing enhanced anti-inflammatory and tissue regeneration effects, making it a promising treatment for acute skin wounds.
Objective: The objective was to develop a manually operatable, non-electric device to measure salivary spinnbarkeit for research, clinical and educational purposes.
Materials And Methods: A newly developed device, named the Kamranmeter, was built and evaluated in a pilot study, comparing the spinnbarkeit of unstimulated and chew-stimulated saliva samples from healthy volunteers. The Neva Meter, which operates on electrical resistance, was used as a reference standard.
Porcine epidemic diarrhea virus (PEDV) is a harmful coronavirus infecting pigs, which is resulting in substantial financial losses in the global pig industry. The lack of effective vaccines or treatments underscores the pressing need for new antiviral strategies. Antimicrobial peptides (AMPs), specifically cathelicidins such as LL-37, have demonstrated promising activity against a range of viruses.
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