Publications by authors named "F Iu Belozertsev"

We have studied the ability of peptide anxiolytic selank (Thr-Lyz-Pro-Arg-Pro-Gly-Pro) to compensate for mnestic dysfunction caused by the administration of actinomycin D, which inhibits protein synthesis by blocking DNA-dependent RNA polymerase. The experiments were performed on white rats with acquired adaptive ability of spatial visual orientation in a 16-door labyrinth. The learning was based on the avoidance of electric skin irritation at alternating sites of escape reaction (site reflex).

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The effect of hypnotic drugs on the brain stability with respect to complete ischemia posttraumatic convulsive reactions and hypoxia has been studied in animals with model brain injury. It is established that zopiclone exhibits pronounced hypnotic effect during the first and second week after brain injury, while nitrazepam, zolpidem, and melaxen are effective in the first week. The neuroprotective effects of zopiclone and zolpidem are more pronounced than those of melaxen and nitrazepam.

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The effect of anticonvulsant drugs on posttraumatic convulsive reactions and the stability of the brain with respect to complete ischemia and hypoxia upon brain injury has been studied in animals with model contact craniocerebral trauma. It is established that lamotrigine, topiramate, and sodium valproate produce a strong effect on convulsive reactions, while magnesium sulfate and gabapentin produce a moderate action. The antiishemic and antihypoxic action of lamotrigine and sodium valproate is stronger than that of topiramate and gabapentin.

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Neuroprotective properties of a series of drugs including nootropes, calcium channel antagonists, and panangin have been studied on a model of craniocerebral trauma. It is established that beglimin and nooglutil exhibit a moderate antiischemic, antihypoxic, and antiamnesic action in posttraumatic period; panangin possesses antiischemic, anticonvulsant, and antiamnesic properties; while nimodipin exhibit only antiamnesic action. It is concluded that beglimin, nooglutil and panangin are of importance in the pharmacological treatment of secondary traumatic brain injury.

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