Publications by authors named "F Itri"
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Article Synopsis
- Acute myeloid leukemia (AML) is a severe blood cancer, with around 30% of cases linked to mutations in the NPM1 gene, leading to a specific classification of NPM1-mutated AML that generally has a favorable prognosis but still faces a high relapse rate of 30-50%.
- This study explored the use of total RNA sequencing (RNAseq) to better characterize NPM1-mutated AML, revealing complex molecular variations and different clonal types that previous methods might have missed, such as abnormal fusion transcripts.
- The findings suggest that advanced technologies like RNAseq could improve risk assessment and treatment planning for patients with NPM1-mutated AML, laying the groundwork for
Article Synopsis
- The COVID-19 pandemic has severely affected individuals with hematological malignancies due to their weakened immune systems, resulting in higher mortality rates and severe outcomes.
- Data from the EPICOVIDEHA registry, which compiles COVID-19 cases from these patients worldwide, was collected from 2020 to 2022, including 8,767 cases from 152 centers across 41 countries.
- Findings show a significant drop in critical infections and overall mortality rates, but hospitalization (especially in ICU) remains a serious risk factor; vaccination is linked to better survival outcomes, highlighting the need for ongoing monitoring and support for these patients.