Publications by authors named "F Itoh"
Transforming growth factor β (TGF-β) is abundantly present in the tumor microenvironment, contributing to cancer progression. However, the regulatory mechanism by which TGF-β affects vascular endothelial cells (ECs) in the tumor microenvironment is not well understood. Herein, we generated tamoxifen-inducible TGF-β type II receptor () knockout mice, specifically targeting ECs (TβRII), by crossbreeding TβRII-floxed mice with Pdgfb-icreER mice.
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- Bone morphogenetic proteins (BMPs) play a key role in the development and differentiation of bone and cartilage, particularly through their interactions with specific receptors on cells.
- In mouse chondrocyte precursor cells (ATDC5), the protein MSK1 is rapidly activated by BMP-6 stimulation, influencing the differentiation processes when either overexpressed or suppressed.
- The study highlights the involvement of both p38 kinase pathways and Smad proteins in BMP-6-induced chondrocyte differentiation, indicating that MSK1 activation is essential for these processes.
Compared with oral or injection administration, percutaneous immunotherapy presents a promising treatment modality for food allergies, providing low invasiveness and safety. This study investigated the efficacy of percutaneous immunotherapy using hen egg lysozyme (HEL)-loaded PLGA-PEG-PLGA nanoparticles (NPs), as an antigen model protein derived from egg white, compared with that of HEL-loaded chitosan hydroxypropyltrimonium chloride (CS)-modified PLGA NPs used in previous research. The intradermal retention of HEL in excised mouse skin was measured using Franz cells, which revealed a 2.
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- Acute immune responses can be deadly due to excess production of cytokines and other harmful substances, creating complex and unpredictable issues in the body.
- Research shows that certain triggers, like toll-like receptor (TLR) ligands and α-adrenergic receptor agonists, can lead to lethal damage in mice by increasing levels of platelet-activating factor (PAF).
- Knocking out specific genes related to immune receptors and enzymes can prevent this damage, highlighting a significant connection between the nervous and immune systems in regulating PAF levels.
Background: Clarithromycin (CAM) resistance is a major contributor to the failure to eradicate Helicobacter pylori (H. pylori). The mixed-infection ratio of CAM-susceptible and CAM-resistant H.
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