Publications by authors named "F Ichou"
Multiple Sclerosis Patient Macrophages Impaired Metabolism Leads to an Altered Response to Activation Stimuli.
Neurol Neuroimmunol Neuroinflamm
November 2024
Article Synopsis
- In multiple sclerosis (MS), immune cells, particularly macrophages, play a dual role in damaging myelin and potentially aiding in its repair, but abnormalities in macrophage responses in MS patients may worsen inflammation and hinder repair processes.
- The study compared the activation of monocytes from MS patients and healthy controls, utilizing RNA sequencing and metabolomics to analyze differences in macrophage behavior and functionality.
- Findings revealed that MS macrophages preferentially activate in a proinflammatory manner, show reduced myelin processing ability, and promote the differentiation of cells toward astrocytes rather than oligodendrocytes, indicating a metabolic dysfunction and persistent inflammatory profile in MS patients.
Background: Antibiotics notoriously perturb the gut microbiota. We treated healthy volunteers either with cefotaxime or ceftriaxone for 3 days, and collected in each subject 12 faecal samples up to day 90. Using untargeted and targeted phenotypic and genotypic approaches, we studied the changes in the bacterial, phage and fungal components of the microbiota as well as the metabolome and the β-lactamase activity of the stools.
View Article and Find Full Text PDFBackground: Left atrial (LA) strain is a simple marker of LA function. The aim of the study was to evaluate the determinants of atrial cardiomyopathy in AF.
Methods: In this pilot study, we prospectively evaluated clinical, biological, metabolomic and echocardiographic parameters for 85 consecutive patients hospitalized for atrial fibrillation (AF) with restoration of sinus rhythm at 6 months.
Sterilized donor milk (DM) is frequently used for feeding preterm infants. To date, the effect of different modes of DM sterilization on short-chain fatty acids (SCFAs) remains unknown. We aimed to quantify SCFAs in DM samples after two types of milk sterilization: the Holder pasteurization (HoP) and a high hydrostatic pressure (HP) processing.
View Article and Find Full Text PDFBackground: Patients with systemic lupus erythematosus (SLE) exhibit a high risk for cardiovascular diseases (CVD) which is not fully explained by the classical Framingham risk factors. SLE is characterized by major metabolic alterations which can contribute to the elevated prevalence of CVD.
Methods: A comprehensive analysis of the circulating metabolome and lipidome was conducted in a large cohort of 211 women with SLE who underwent a multi-detector computed tomography scan for quantification of coronary artery calcium (CAC), a robust predictor of coronary heart disease (CHD).