[The clinicofunctional characterization of the phenotypes of severe uncontrollable bronchial asthma].

The aim of the study was to compare the clinical characteristics and the inflammatory process activity in the airway of patients with severe therapy-sensitive and therapy-resistant bronchial asthma (TSBA; TRBA). The subjects were 171 patients with severe bronchial asthma (BA) aged 18 to 60; the diagnosis was established prior to the study according to GINA 2002 criteria. There were 50 TSBA patients, 121 TRBA, and 50 controls.

[Monitoring and treatment of severe bronchial ashma in adults: results of national multicenter trial NABAT].

Aim: To study quality of monitoring, features of a course and therapy of severe bronchial asthma (BA) in Russia.

Materials And Methods: The trial recruited 378 patients with severe bronchial asthma (SBA) in 7 cities of Russia. Each center participating in the study filled in individual case sheets recording demographic, clinical, monitoring, pharmacotherapeutic data.

IL-5 expression in the sputum of patients with bronchial asthma.

Expression of IL-5 mRNA and the content of IL-5 in the sputum of patients with asthma of different severity were studied before and after treatment. The expression of IL-5 mRNA in mild asthma differed from that in severe and moderate asthma before and after treatment. The level of IL-5 before therapy was different in patients with mild and severe disease.