Publications by authors named "F I Forster"
The long-tern implications of stress during university for individuals' mental health are not well understood so far. Hence, we aimed to examine the potential effect of stress while studying at university on depression in later life. We analysed data from two waves of the longitudinal Study on Occupational Allergy Risks.
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- Crypt4GH-JS is a JavaScript library that enables on-the-fly encryption for web applications without significantly affecting data transfer speeds.
- It supports secure data storage in cloud environments, addressing the growing need for flexible data security solutions.
- The library can be installed via Node Package Manager or accessed on GitHub, and users can also test it through an online demonstration site.
Background: Using disinfectants and cleaning products (DCPs) at home and work is known to influence both the onset and course of asthma, but most epidemiological studies did not consider the multiplicity and correlations of exposures to DCPs. We aimed to identify exposure profiles for the long-term weekly use of DCPs by latent class analysis (LCA) and assess their associations with asthma.
Methods: LCA was conducted on data from 1143 young adults initially recruited in the German centers of Phase II of the International Study of Asthma and Allergies in Childhood (ISAAC) and followed up three times.
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- Secretory proteins rely on the signal peptidase complex (SPC) for proper processing of their signal sequences, which is vital for correct protein folding and placement in eukaryotic cells.
- The study focused on the role of Spc2 within the SPC, showing that mutations or depletion of Spc2 hinder the complex’s ability to recognize and cleave substrates correctly.
- Molecular dynamics simulations revealed that without Spc2, the SPC's membrane structure is altered, shedding light on how Spc2 affects the protein biogenesis process.
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- Microtubules are vital components of cells, regulated by mechanisms like posttranslational modifications and associated proteins, with recent research indicating that the microtubule lattice's conformation is also a regulatory factor.
- Using cryo-electron tomography, the study reveals most microtubules have a compact lattice, but about 25% show expanded lattice spacings, especially when treated with the stabilizing agent Taxol.
- The findings suggest a link between lattice spacing and microtubule stability, with stable microtubules tending to have a more expanded lattice, highlighting the importance of lattice configuration in defining microtubule types.