Postpartum Treatment With Immunoglobulin Does Not Prevent Relapses of Multiple Sclerosis in the Mother.

Multiple sclerosis (MS) is a chronic, neurological, immune-mediated disease that can worsen in the postpartum period. There is no consensus on the use of immunoglobulin for prevention of disease relapses after delivery. We have shown that the controversial beneficial effect of immunoglobulin given immediately after birth could not be observed in patients with MS.

Evolving granular neural networks from fuzzy data streams.

This paper introduces a granular neural network framework for evolving fuzzy system modeling from fuzzy data streams. The evolving granular neural network (eGNN) is able to handle gradual and abrupt parameter changes typical of nonstationary (online) environments. eGNN builds interpretable multi-sized local models using fuzzy neurons for information fusion.

Spectroscopic and thermodynamic properties of Debaryomyces hansenii UFV-1 alpha-galactosidases.

Spectroscopic and thermodynamic properties were determined for Debaryomyces hansenii UFV-1 extracellular and intracellular alpha-galactosidases. alpha-Galactosidases showed similar secondary structure compositions (alpha-helix, beta-sheet parallel and beta-turn). Effects of pH and temperature on the structure of alpha-galactosidases were investigated using circular dichroism spectroscopy.

Design of fuzzy systems using neurofuzzy networks.

This paper introduces a systematic approach for fuzzy system design based on a class of neural fuzzy networks built upon a general neuron model. The network structure is such that it encodes the knowledge learned in the form of if-then fuzzy rules and processes data following fuzzy reasoning principles. The technique provides a mechanism to obtain rules covering the whole input/output space as well as the membership functions (including their shapes) for each input variable.

Physical-chemical characterization and stability study of alpha-trypsin at pH 3.0 by differential scanning calorimetry.

alpha-Trypsin is a serine-protease with a polypeptide chain of 223 amino acid residues and six disulfide bridges. It is a globular protein with predominance of antiparallel ss-sheet secondary structure and it has two domains with similar structures. In the present work, a stability study of alpha-trypsin in the acid pH range was performed and some physical-chemical denaturation parameters were measured by using differential scanning calorimetry (DSC).