Muscle chemoreflex alters carotid sinus baroreflex response in humans.

The arterial baroreflex opposes pressor responses to muscle ischemia (muscle chemoreflex). Our experiments sought to quantify the unknown effects of muscle chemoreflex on carotid sinus baroreflex (CSB) sensitivity. We generated CSB stimulus-response (S-R) curves by pulsatile application (triggered by each electrocardiogram R wave) of positive and negative neck pressure (from 60 to -80 mmHg in 20-mmHg steps of 20 s each) in seven normal young men.