[Evidence-based medicine: implications from the guideline "non-invasive ventilation" in critically ill elderly patients].

The demographic shift means that there are an increasing number of elderly critically ill patients with various comorbidities. This very specific group needs particular treatment which has not been considered sufficiently in medical guidelines so far. To improve health care, it is indispensable not only to work out the current guidelines, but aspects of geriatric medicine must also be integrated into future developments.

[Hemochromatosis. Determination of the C282Y mutation frequency in the population of the Czech Republic and sensitivity of hemochromatosis detection using Guthrie cards].

Background: Hereditary haemochromatosis (HH) is a multi-organ disease characterized by increased deposition of iron in some tissues. When discovered early the disease is curable. The Caucasian population is burdened with a high incidence of carriers and homozygotes.

Influence of metronidazole and tamoxifen in a case of otherwise untreated ulcerous breast carcinoma.

A 78-year-old patient with an ulcerous, purulent, exophytic fist-sized breast carcinoma (FIGO IVd) and a pulmonary metastasis who refused radiation, chemotherapy and operation, was treated with oral tamoxifen and metronidazole daily and with local antiseptics. After two months she was pain-free without analgesics. After eight months the exophytic part of the tumor had completely gone.

Study of pharmacokinetics and pharmacodynamics of two preparations of metoclopramide.

A pharmacokinetic-pharmacodynamic cross-over study in a group of volunteers (8 male, 4 female) was performed to evaluate the activity and plasma levels of a new sustained-release metoclopramide (CAS 364-62-5) formulation (Cronoprimperan) in comparison to a standard formulation (Primperan). During the course of this trial volunteers on both medications complained of mild to moderate adverse effects as headaches and drowsiness. Elevated monocyte counts were seen in all volunteers at the end of the study without determinable relationship to the medications.