Diarylformamides as a Safe Reservoir and Room Temperature Source of Ultra-Pure CO in the Context of a 'Green' rWGS Reaction.

Diphenylformamide 1 and bisformamide 9 are shown to be safe reservoirs and sources of CO. Their perfectly selective decarbonylations are achieved in solution at room temperature with potassium and cesium diarylamide catalysts. 1 is obtained in excellent yields directly from triethylammonium formate, which may be the product of CO scrubbing with NEt and catalytic hydrogenation.

Impairment of myocardial calcium homeostasis by antibodies against the adenine nucleotide translocator.

The adenine nucleotide translocator (ANT) is an autoantigen in myocarditis and dilated cardiomyopathy. Carrier-specific antibodies impair myocardial energy metabolism and heart function. They cross-react with a myolemmal calcium channel and alter calcium fluxes in isolated myocytes.

Effect of substrate on mitochondrial NADH, cytosolic redox state, and phosphorylated compounds in isolated hearts.

The effect of metabolic substrates on the relation among cytosolic redox state (NADHc/NAD+) mitochondrial NADH (NADHm), and [ATP]/([ADP] x [Pi]) was studied in isolated working rabbit hearts. Substrates were varied from 5.6 mM glucose alone to glucose in combination with 10 mM lactate and/or 10 mM pyruvate while afterload and preload were held constant.

The relationship between phosphorylation potential and redox state in the isolated working rabbit heart.

The effects of the cytosolic and mitochondrial redox state on the function and phosphorylation potential of working perfused rabbit hearts were studied. Hearts were perfused with glucose, while lactate, aminooxy-acetate (an inhibitor of the malate-aspartate shuttle), beta-hydroxybutyrate, and pyruvate were sequentially added to the perfusate to manipulate the cytosolic and mitochondrial NAD+/NADH ratio. The phosphorylation potential and product of ADP and P(i) were both found to be proportional to mitochondrial redox state.