Publications by authors named "F Haspot"
Article Synopsis
- Tumor evasion is linked to HHLA2, a new member of the B7 family, often found in PDL-1 tumors, which interacts differently with immune cells by either stimulating or inhibiting them.
- A study compared two monoclonal antibodies targeting CD28H, showing that specific targeting can enhance NK-cell activation and boost their ability to combat cancer cells.
- Analysis of clear cell renal cancer indicated the presence of CD28H NK cells in HHLA2 tumors, suggesting potential for effective treatment using tailored anti-CD28H antibodies.
Article Synopsis
- Graft-versus-host disease (GvHD) is a serious problem that can happen after getting a stem cell transplant.
- Researchers found that a special kind of cells called DP8α Tregs, which help control the immune system, might help prevent GvHD by linking to helpful gut bacteria.
- The study showed that patients with fewer DP8α Tregs were more likely to develop GvHD, suggesting that boosting these cells could be important for preventing this disease.
Development and characterization of a humanized mouse model of osteoarthritis.
Osteoarthritis Cartilage
June 2022
Objective: In light of the role of immune cells in OA pathogenesis, the development of sophisticated animal models closely mimicking the immune dysregulation during the disease development and progression could be instrumental for the preclinical evaluation of novel treatments. Among these models, immunologically humanized mice may represent a relevant system, particularly for testing immune-interacting DMOADs or cell therapies before their transfer to the clinic. Our objective, therefore, was to develop an experimental model of OA by destabilization of the medial meniscus (DMM) in humanized mice.
View Article and Find Full Text PDFA numerous number of positive and negative signals various molecules modulate T-cell activation. Within the various transmembrane proteins, SIRPγ is of interest since it is not expressed in rodents. SIRPγ interaction with CD47 is reevaluated in this study.
View Article and Find Full Text PDFThe success of inducing human pluripotent stem cells (hIPSC) offers new opportunities for cell-based therapy. Since B cells exert roles as effector and as regulator of immune responses in different clinical settings, we were interested in generating B cells from hIPSC. We differentiated human embryonic stem cells (hESC) and hIPSC into B cells onto OP9 and MS-5 stromal cells successively.
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