Publications by authors named "F Hamedi-Sangsari"
Article Synopsis
- The addition of 4-methylthio-2-oxobutanoate (MTOB) helps methionine-dependent cancer cells grow without methionine and transition state inhibitors can selectively target these cancer cells for inhibition.
- The transition state analogue L-methionine ethyl ester pyridoxal (MEEP) and the amine donor analogue D-aspartate beta hydroxamate (D-AH) effectively inhibit the MTOB transaminase enzyme in cancer cells, promoting apoptosis without affecting normal cells.
- MEEP shows 20 times greater efficacy than D-AH in inducing cancer cell death, highlighting MTOB transaminase as a promising target for developing selective anticancer therapies.
Binding of the antiretroviral drug, d-aspartate-β-hydroxamate on the NMDA receptor.
Environ Toxicol Pharmacol
December 1996
d-Aspartate-β-hydroxamate (d-A β H) exhibits antiretroviral properties in vitro and in vivo. It has glutamate agonist properties at the N-methyl-d-aspartate (NMDA) receptor in neuronal cell cultures. This study characterizes its binding properties to the NMDA receptor by measuring its stimulating effect on N-(1-(2-thienyl)[(3)H]cyclohexyl)piperidine ([(3)H]TCP) binding to the ionic channel in rat brain membranes.
View Article and Find Full Text PDFAnti-HIV activity of the combination of didanosine and hydroxyurea in HIV-1-infected individuals.
J Acquir Immune Defic Syndr Hum Retrovirol
September 1995
HIV is known to be present in massive amounts in both resting and actively replicating cells in infected individuals. We tested the combination of didanosine and hydroxyurea, known to suppress viral production in vitro in both of these cell types, in a small number of asymptomatic patients. After 3 months of well tolerated treatment, we observed a large reduction of viral load in the peripheral blood of all 12 patients, down to nonquantifiable levels in 7 of 12 as measured by infectious virus titer, and 6 of 12 as measured by plasma HIV-RNA.
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