The Use of Clot Strength as a Predictor of Thrombosis in Peripheral Artery Disease.

Background: Graft/stent thrombosis is the leading cause of amputation in patients over 60, and while dual antiplatelet therapy is the standard of care, there is a significant variability in platelet response and limited guidance on measuring effectiveness. Thromboelastography with platelet mapping (TEG-PM) can objectively detail an individual's coagulation profile, namely the strength of the clot and its response to antiplatelet medication. Although TEG-PM has been used for predicting postoperative bleeding and assessing platelet dysfunction in traumatic brain injury, its application in thrombosis diseases such as peripheral artery disease remains unexplored.

The role and interplay of institutions in water governance in the Central Rift Valley of Ethiopia.

Background: Institutions can play a key role in coordinating how natural resources are effectively managed and used without over-exploitation. Institutions are laws, policies, and organizational arrangements that permit, forbid or regulate human action. This study aimed to look into the roles of formal and informal institutions, and their interactions in water resources governance in the Central Rift Valley (CRV), Ethiopia.

Understanding Water Governance in the Central Rift Valley of Ethiopia: Governance Framework, Coherence and Practices.

Water governance demands multi-sector participation beyond the state; and, appropriate laws, policies, regulations, and institutions need to be developed and put in place for sustainable use of water resources. A good water policy, a critical and integral instrument of water governance, guides water use schemes and ensures equitable water distribution among users. The Ethiopian Central Rift Valley (CRV) is rich in water resources, but these water resources are currently under severe strain owing to an imbalance in human-water interactions.

Safety and Tolerability of the APOL1 Inhibitor, Inaxaplin, following Single- and Multiple-Ascending Doses in Healthy Adults.

Introduction: Toxic gain-of-function () variants contribute to the development of proteinuric nephropathies collectively referred to as APOL1-mediated kidney disease (AMKD). Despite standard-of-care treatments, patients with AMKD experience accelerated progression to end-stage kidney disease. The identification of two variants as the genetic cause of AMKD inspired development of inaxaplin, an inhibitor of APOL1 channel activity that reduces proteinuria in patients with AMKD.