Publications by authors named "F HaeSSler"
Article Synopsis
- - The study explores how changes in the lipid composition of CD8 effector T cells influence their differentiation and signaling, specifically focusing on different types of phosphoinositides (PIP).
- - Naive T cells predominantly contain polyunsaturated PIP, which supports immediate signaling after T cell activation, while late T cells rely on saturated PIP for ongoing signaling due to decreased activity of the enzyme phospholipase C-γ1.
- - The research found that glucose is crucial for the production of saturated PIP, suggesting that different lipid profiles with distinct fatty acid compositions are critical for the successful functioning of T cells during their differentiation process.
Article Synopsis
- * A lack of the enzyme ornithine decarboxylase, essential for polyamine production, leads to improper CD4 T cell specification and abnormal expression of cytokines and transcription factors.
- * Polyamines influence T cell differentiation by generating hypusine, with a deficiency in this process resulting in significant epigenetic changes and severe intestinal inflammation in mice.
Introduction: Sleep, circadian rhythms, (mental) health, and development are assumed to be intertwined. However, differentiated and reliable parameters of sleep and circadian rhythms are particularly difficult to assess for Fragile X (FXS) individuals. As those parameters need to be observed in complex settings, the feasibility of measurements for people with FXS was to be proven.
View Article and Find Full Text PDFCompetition for nutrients like glucose can metabolically restrict T cells and contribute to their hyporesponsiveness during cancer. Metabolic adaptation to the surrounding microenvironment is therefore key for maintaining appropriate cell function. For instance, cancer cells use acetate as a substrate alternative to glucose to fuel metabolism and growth.
View Article and Find Full Text PDFObjective: This study explores the care situation of children and adolescents with intellectual disabilities (ID) suffering from mental problems in Germany in 2014. It complements the study of Hennicke, which was conducted a decade ago.
Method: All clinics and departments of child and adolescent psychiatry in Germany (n=138) were contacted via mail or personally and requested to fill out a questionnaire.