Breast cytology. Statistical analysis and cytohistologic correlations.

Objective: To analyze the sensitivity, specificity, positive and negative predictive values and the efficacy of fine needle aspiration (FNA) in our material, to investigate the influence of the histologic type and stage of carcinoma on the quality of the aspirates and on the detection rates of mammary carcinoma, and to investigate the rate of inadequate samples and the accuracy of cytologic diagnoses, with an emphasis on the rate of false positive diagnoses in benign mammary lesions.

Study Design: The results of 1,472 FNAs of the breast obtained over three years were subjected to a retrospective analysis.

Results: The cytologic diagnoses were benign in 1,003 cases (68.

No tumor-specific expression levels of protein kinase C isoenzymes and of c-fos in human breast cancer cell cultures.

Epithelial cells derived from 46 human breast tissue samples of patients suffering from breast cancer have been cultivated. Twenty-five of these cell cultures stemmed from normal and 21 from tumor tissues. Moderate to large variations of protein levels of three protein kinase C (PKC) isoenzymes (alpha, delta and epsilon) were found among the various cell cultures.

[Sarcoma of the breast: what is the contribution of immunohistochemistry and flow cytometry?].

Only 0.2-1% of all mammary malignancies are sarcomas of the breast. This study includes 4 cases: 2 osteosarcomas, 1 fibrosarcoma, and 1 malignant undifferentiated stromal sarcoma.

[Rare breast tumors].

The cystosarcoma phylloides, like the sarcoma, represents 0.3 to 0.9% of all tumors of the breast.