Flavonifractor Plautii or Its Metabolite Desaminotyrosine as Prophylactic Agents for Alleviating Myocardial Ischemia/Reperfusion Injury.

Myocardial ischemia/reperfusion (I/R) injury is a major contributor to myocardial damage, leading to adverse cardiac remodeling and dysfunction. Recent studies have highlighted the potential of gut microbiota-derived metabolites in modulating cardiac outcomes. Here, the cardioprotective effects of a commensal bacterium Flavonifractor plautii (F.

Natural variation and CRISPR/Cas9 gene editing demonstrate the potential for a group VII ethylene response factor HvERF62 in regulating barley (Hordeum vulgare L.) waterlogging tolerance.

Waterlogging stress is a serious problem all over the world, which inhibits plant growth and development, and even leads to plant death in severe circumstances. Ethylene-responsive VII transcription factor (ERFVII) is a key factor regulating plant waterlogging tolerance. In this study, a major QTL conferring chlorophyll content under waterlogging stress was detected on chromosome 4H through GWAS using a natural population.

Maternal di(2-ethylhexyl) phthalate exposure increases the risk of congenital heart disease in mice offspring.

Abstrct: BACKGROUD: Epidemiological data suggest that maternal occupational exposure to mixed phthalates comprising di(2-ethylhexyl) phthalate (DEHP) increases the risk of congenital heart disease (CHD). In this study, we used mice as an animal model to validate impact of first-trimester DEHP exposure on the risk of CHD in offspring, to elucidate the possible mechanisms and to provide a potential feasible intervention.

Methods And Results: Eight-week-old C57BL/6J pregnant mice were randomly divided into standard and DEHP diet groups.

PRC1 promotes ovarian cancer progression by binding to RPL4 and increasing MDM2-mediated p53 ubiquitination.

Ovarian cancer (OC) is one of the most fatal gynecological carcinomas, causing significant detriment to women's health. Protein regulator of cytokinesis 1 (PRC1) is a microtubule-associated protein that is found to be highly expressed in many different cancers. Despite this, the exact way in which PRC1 stimulates the growth of OC has yet to be completely understood.

Aberrant expansion of CD177 neutrophils promotes endothelial dysfunction in systemic lupus erythematosus via neutrophil extracellular traps.

Objective: Aberrant neutrophil activation is implicated in the pathogenesis of systemic lupus erythematosus (SLE) and its related comorbidities. We found that CD177 was one of the most highly up-regulated genes at the transcriptional level in purified neutrophils from SLE patients. In this study, we aimed to explore the role of CD177 neutrophils in the pathogenesis of SLE.