Measuring Total Metabolic Tumor Volume from F-FDG PET: A Reality Check.

Measuring total metabolic tumor volume (TMTV) on F-FDG PET/CT images in clinical practice requires a fast, reliable, and easy-to-perform multilesional segmentation workflow. We conducted a field test to derive total metabolic volumes using 5 representative baseline F-FDG PET/CT scans from patients with diffuse large B-cell lymphoma. The scans were transferred to 10 different sites or readers who used different commercially available software platforms to derive TMTV after a recently proposed benchmark workflow.

Automated segmentation of the sacro-iliac joints, posterior spinal joints and discovertebral units on low-dose computed tomography for Na[F]F PET lesion detection in spondyloarthritis patients.

Purpose: Spondyloarthritis (SpA) is a chronic inflammatory rheumatic disease which involves the axial skeleton. Quantitative sodium fluoride-18 (Na[F]F) PET/CT is a new imaging approach promising for accurate diagnosis and treatment monitoring by assessment of molecular bone pathology in SpA. Detection of Na[F]F PET positive lesions is time-consuming and subjective, and can be replaced by automatic methods.

Deep learning image enhancement algorithms in PET/CT imaging: a phantom and sarcoma patient radiomic evaluation.

Purpose: PET/CT imaging data contains a wealth of quantitative information that can provide valuable contributions to characterising tumours. A growing body of work focuses on the use of deep-learning (DL) techniques for denoising PET data. These models are clinically evaluated prior to use, however, quantitative image assessment provides potential for further evaluation.

[F]FDG administered activity reduction capabilities of a 32-cm axial field-of-view solid-state digital bismuth germanium oxide PET/CT system while maintaining EARL compliance.

Purpose: To assess the lower [F]FDG limit in administered activity and/or scan time reduction capabilities of a digital-BGO 32-cm axial field-of-view PET system while being compliant with current and updated EANM Research Ltd Fluorine-18 accreditation specifications (EARL and EARL).

Methods: EARL and EARL compliance of the digital-BGO system (Omni Legend 32 cm) was tested for several reconstructions, including those that apply precision deep learning-based image enhancement (PDL) as postprocessing, using the calibration QC and NEMA IEC phantom measurements. The image quality QC scan was repeated every hour for 7 h, with each subsequent hour representing a lower administered activity, and reconstructed for various times per bed position, i.

Baseline PSMA PET/CT parameters predict overall survival and treatment response in metastatic castration-resistant prostate cancer patients.

Objective: Metastatic castration-resistant prostate cancer (mCRPC) is a heterogeneous disease with varying survival outcomes. This study investigated whether baseline PSMA PET/CT parameters are associated with survival and treatment response.

Methods: Sixty mCRPC patients underwent [F]PSMA-1007 PET/CT before treatment with androgen receptor-targeted agents (ARTAs) or chemotherapy.