Test-retest variability of various quantitative measures to characterize tracer uptake and/or tracer uptake heterogeneity in metastasized liver for patients with colorectal carcinoma.

Purpose: The aim of this study was to assess test-retest variability of various quantitative measures to characterize tracer uptake and/or tracer uptake heterogeneity.

Procedures: Two baseline whole-body 2-deoxy-2-[(18)F]fluoro-D-glucose positron emission tomography/computed tomography (CT) scans were acquired in 29 subjects with colorectal carcinoma. Whole liver volumes of interest (VOI) were defined manually on CT.

Non-invasive monitoring of commonly used intraocular drugs against endophthalmitis by Raman spectroscopy.

Purpose: To develop a non-contact and non-invasive method for quantification of the local concentration of certain antibiotic and antifungal drugs in the eye.

Study Design/materials And Methods: An integrated CCD-based Raman spectroscopic system designed specifically for ophthalmic applications was used to non-invasively detect the presence of ceftazidime and amphotericin B in ocular media. Specific Raman signatures of the above named drugs were determined for various concentrations that were injected through a needle in the aqueous humor of rabbit eyes in vivo.

Noninvasive detection of ganciclovir in ocular tissue by Raman spectroscopy: implication for monitoring of drug release.

Unlabelled: Treatment of various pathological conditions in ophthalmology, such as cytomegalovirus (CMV) retinopathy and endophthalmitis, requires a local drug intervention rather than a systemic approach. Accurate knowledge of intraocular drug concentration can permit the ophthalmologist to maintain drug levels within the therapeutic levels necessary for an optimal prognosis, while preventing or minimizing toxicity associated with drug overdose.

Purpose: To develop a noninvasive/noncontact method for quantification of the local concentration of ganciclovir in the ocular media.

Tailoring of new polymeric biomaterials for the repair of medium-sized corneal perforations.

The aim of this study was to investigate whether polymeric biomaterials can be designed such that they become suitable for surgical closure of medium-sized perforations in the cornea, the transparent tissue in the front of the eye. Such a biomaterial must meet stringent requirements in terms of hydrophilicity, strength, transparency, flexibility, and biocompatibility. Four different copolymers of n-butyl methacrylate (BMA) and hexa(ethylene glycol) methacrylate (HEGMA) were prepared and characterized.