Publications by authors named "F H Hezemans"
Noradrenaline is a powerful modulator of cognitive processes, including action decisions underlying saccadic control. Changes in saccadic eye movements are common across neurodegenerative diseases of ageing, including Parkinson's disease. With growing interest in noradrenergic treatment potential for non-motor symptoms in Parkinson's disease, the temporal precision of oculomotor function is advantageous to assess the effects of this modulation.
View Article and Find Full Text PDFBackground: Impulse control disorders (ICDs) in Parkinson's disease are associated with a heavy burden on patients and caretakers. While recovery can occur, ICDs persist in many patients despite optimal management. The basis for this interindividual variability in recovery is unclear and poses a major challenge to personalized health care.
View Article and Find Full Text PDFBackground: Early adverse experiences are assumed to affect fundamental processes of reward learning and decision making. However, computational neuroimaging studies investigating these circuits in the context of adversity are sparse and limited to studies conducted in adolescent samples, leaving the long-term effects unexplored.
Methods: Using data from a longitudinal birth cohort study (n = 156; 87 female), we investigated associations between adversities and computational markers of reward learning (i.
Parkinson's disease (PD) and progressive supranuclear palsy (PSP) both impair response inhibition, exacerbating impulsivity. Inhibitory control deficits vary across individuals and are linked with worse prognosis, and lack improvement on dopaminergic therapy. Motor and cognitive control are associated with noradrenergic innervation of the cortex, arising from the locus coeruleus (LC) noradrenergic system.
View Article and Find Full Text PDFArticle Synopsis
- Individual differences in dopamine synthesis capacity have been linked to working memory, impulsivity, and spontaneous eye-blink rate, suggesting simple tests could estimate dopamine levels instead of expensive PET scans.
- A study with 94 healthy volunteers assessed the correlation between these traits and striatal dopamine synthesis capacity using PET imaging.
- The findings showed no significant correlations, indicating that these simple tests should not be relied upon as substitutes for directly measuring striatal dopamine synthesis capacity.