Publications by authors named "F H H Brill"

Article Synopsis
  • Microorganisms in Arctic environments show antimicrobial resistance, with various bacterial isolates exhibiting resistance to common antimicrobials like erythromycin, tetracycline, and colistin.
  • Whole genome sequencing revealed that many of these isolates, particularly from Micromonospora, Pseudomonas, and Pedobacter, carry genes that confer resistance not only to antibiotics but also to heavy metals and disinfectants.
  • This research underscores the significance of protecting Arctic ecosystems from human impact, as the presence of these resistance genes could threaten both environmental and public health in the context of climate change.
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In addition to emissions harmful to the environment, a significant amount of waste is generated in hospitals. In recognition of the fact that medical devices (MDs) contain valuable raw materials, such as rare earth elements, other metals, and high-quality plastics, a recycling concept has been developed. The project was examined for safety and feasibility from a hygiene point of view with sustainability in mind in order to create a reference solution for other areas as applicable.

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Background: Respiratory viruses have been reported to infect the salivary glands and the throat, which are potential reservoirs for virus replication and transmission. Therefore, strategies to reduce the amount of infective virus particles in the oral mucous membranes could lower the risk of transmission.

Methods: The viral inactivation capacity of a plant-oil-based oral rinse (Salviathymol®) was evaluated in comparison with chlorhexidine (Chlorhexamed® FORTE) using a quantitative suspension test according to EN 14476.

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To investigate the effectiveness of antimicrobial agents against wound infections, experiments using either 2D cultures with planktonic microorganisms or animal infection models are frequently carried out. However, the transferability of the results to human skin is limited by the lack of complexity of the 2D models or by the poor translation of the results from animal models. Hence, there is a need for wound infection models capable of assessing antimicrobial agents.

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Aims: We aimed to develop a method to assess the virucidal performance of domestic laundry in a lab-scale washing machine (Rotawash) based on EN 17658.

Methods And Results: For method development, virus recovery was investigated after drying on cotton carriers for three test viruses murine norovirus (MNV), modified vaccinia virus Ankara (MVA), and bovine coronavirus (BCoV), followed by washing simulations in flasks and Rotawash. MNV and MVA demonstrated sufficient recovery from carriers after drying and washing (up to 40°C and 60 min).

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