Publications by authors named "F H Gabbay"
Background: Respiratory viral infections are major drivers of chronic obstructive pulmonary disease (COPD) exacerbations. Interferon-β is naturally produced in response to viral infection, limiting replication. This exploratory study aimed to demonstrate proof-of-mechanism, and evaluate the efficacy and safety of inhaled recombinant interferon-β1a (SNG001) in COPD.
View Article and Find Full Text PDFImportance: Posttraumatic stress disorder (PTSD) is a prevalent mental health problem that increases risk of cardiovascular disease (CVD). It is not known whether gender or comorbidities modify associations between PTSD and CVD.
Objective: To assess risk of hypertension and atherosclerotic CVD (ASCVD) associated with PTSD in a predominantly young military population, and determine if gender or PTSD comorbidities modify these associations.
Article Synopsis
- The study focuses on improving treatment for military personnel suffering from insomnia by using a machine learning model to predict responses to cognitive behavioral therapy for insomnia (CBT-I).
- The model analyzed data from 1,449 US Army soldiers and achieved a prediction accuracy of about 60%, identifying significant predictors like insomnia severity and suicidal ideation.
- The results suggest that using this model could help target individuals who are more likely to benefit from CBT-I, promoting a personalized approach to insomnia treatment in military settings.
Study Objectives: Although many military personnel with insomnia are treated with prescription medication, little reliable guidance exists to identify patients most likely to respond. As a first step toward personalized care for insomnia, we present results of a machine-learning model to predict response to insomnia medication.
Methods: The sample comprised n = 4,738 nondeployed US Army soldiers treated with insomnia medication and followed 6-12 weeks after initiating treatment.
Background: Despite the availability of vaccines and therapies, patients are being hospitalised with coronavirus disease 2019 (COVID-19). Interferon (IFN)-β is a naturally occurring protein that stimulates host immune responses against most viruses, including severe acute respiratory syndrome coronavirus 2. SNG001 is a recombinant IFN-β1a formulation delivered to the lungs nebuliser.
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