Publications by authors named "F H Boot"
Background: People with intellectual disability have a poorer health status than the general population. In The Netherlands, support workers play a key role in meeting health support needs of people with intellectual disability. Research on how people with intellectual disability and their support workers experience the support worker's role in preventing, identifying, and following up health needs of people with intellectual disability is scarce.
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- Access to Human Beta Cells
- : The study presents EndoC-βH5 cells as an advanced model for understanding human pancreatic beta cell functions and potential diabetes treatments, closely mimicking primary adult cells.
- Cell Generation and Features
- : These cells were created by integrating specific genes into human fetal pancreas, with successful removal of unwanted transgenes, resulting in cells that are easy to use and assess for insulin secretion and other functions.
- Findings and Applications
- : EndoC-βH5 cells demonstrate strong glucose-dependent insulin secretion and are suitable for drug testing and studying beta cell behavior, indicating their utility in diabetes research and therapy.
Insulin secretion in pancreatic β-cells is regulated by cortical complexes that are enriched at the sites of adhesion to extracellular matrix facing the vasculature. Many components of these complexes, including bassoon, RIM, ELKS and liprins, are shared with neuronal synapses. Here, we show that insulin secretion sites also contain the non-neuronal proteins LL5β (also known as PHLDB2) and KANK1, which, in migrating cells, organize exocytotic machinery in the vicinity of integrin-based adhesions.
View Article and Find Full Text PDFBackground: Whilst assistive technology (AT) can play an important role to improve quality of life, health inequity regarding access to appropriate AT for people with intellectual disabilities (ID) is still very much present especially in low resource countries.
Objectives: This study focused on exploring factors that influence access to and continued use of AT by people with ID in the Western Cape province of South Africa and to suggest potential implications of these findings and actions required to promote access to AT.
Method: A qualitative approach was used to explore the experiences of people with ID and providers of AT.