Publications by authors named "F Guenther"
Inhibition of the mitochondrial deubiquitinating (DUB) enzyme USP30 is neuroprotective and presents therapeutic opportunities for the treatment of idiopathic Parkinson's disease and mitophagy-related disorders. We integrated structural and quantitative proteomics with biochemical assays to decipher the mode of action of covalent USP30 inhibition by a small-molecule containing a cyanopyrrolidine reactive group, . The inhibitor demonstrated high potency and selectivity for endogenous USP30 in neuroblastoma cells.
View Article and Find Full Text PDFBackground: Recently, several novel RSV immunisation products that protect infants and older adults against RSV disease have been licensed in Europe. We estimated the effectiveness and efficiency of introducing these RSV immunisation strategies in Germany.
Methods: We used a Bayesian framework to fit a deterministic age-structured dynamic transmission model of RSV to sentinel surveillance and RSV-specific hospitalisation data in Germany from 2015 to 2019.
Article Synopsis
- The study investigates how abstract and concrete concepts are processed in the brain, highlighting the "concreteness effect" where concrete words are understood faster and more accurately than abstract words.
- Researchers establish a connection between phonological features of words and their concreteness ratings, finding that specific attributes like syllable count and phonological neighbors play a role.
- Results show that these phonological features significantly affect lexical processing across various language tasks, suggesting that models of language processing should consider the non-arbitrary relationship between word form and meaning.
The purpose of this article is to review the scientific literature concerning speech in Parkinson's disease (PD) with reference to the DIVA/GODIVA neurocomputational modeling framework. Within this theoretical view, the basal ganglia (BG) contribute to several different aspects of speech motor learning and execution. First, the BG are posited to play a role in the initiation and scaling of speech movements.
View Article and Find Full Text PDFArticle Synopsis
- Stuttering affects about 1 in 100 adults, leading to communication issues and social anxiety, often appearing as a developmental disorder but sometimes linked to brain damage.
- The study analyzed three groups: patients with stroke-induced stuttering, a clinical cohort with similar issues, and adults with persistent developmental stuttering, to uncover the brain regions involved.
- Results showed that brain lesions from stuttering are connected to a common network centered around the left putamen, with significant correlations to stuttering impact in participants with developmental stuttering.