Publications by authors named "F Guehenneux"
Chikungunya virus (CHIKV) is a reemerging mosquito-borne alphavirus responsible for numerous outbreaks. Chikungunya can cause debilitating acute and chronic disease. Thus, the development of a safe and effective CHIKV vaccine is an urgent global health priority.
View Article and Find Full Text PDFVaccines have been used for centuries to protect people and animals against infectious diseases. For vaccine production, it has become evident that cell culture technology can be considered as a key milestone and has been the result of decades of progress. The development and implementation of cell substrates have permitted massive and safe production of viral vaccines.
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- Monoclonal antibodies (mAbs) are rapidly growing in popularity as therapeutic proteins, prompting the need for more efficient manufacturing processes.
- Researchers have found that the EB66 cell line, derived from duck embryonic stem cells, can produce mAbs at high yields (over 1 g/L) in serum-free conditions.
- This cell line also exhibits favorable growth properties, such as a short doubling time and low waste accumulation, while its mAbs have reduced fucose content which enhances their effectiveness in immune responses.
Background: Several recent reports have connected protein methylation with differentiation. Furthermore, the BTG/TOB proteins have also been implicated in such control. BTG1 and 2 have been shown to interact with PRMT1 (predominant cellular arginine N-methyltransferase of type I).
View Article and Find Full Text PDFIt is well known that loss of tumor suppressor genes and more generally of antiproliferative genes plays a key role in the development of most tumors. We report here the cloning of the mouse BTG3 gene and show that its human counterpart maps on chromosome 21. This evolutionarily conserved gene codes for a 30 kDa protein and is expressed in most adult murine and human tissues analyzed.
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