Publications by authors named "F Grodstein"
Introduction: Social activity is associated with better cognitive health in old age. To better translate epidemiological research for public health communication, we estimated relations of levels of social activity to average age at dementia onset.
Methods: In the Rush Memory and Aging Project (MAP), we followed 1923 dementia-free older adults and conducted annual clinical evaluations of dementia/mild cognitive impairment (MCI).
Article Synopsis
- - The study aimed to understand brain aging by developing a cortical epigenetic clock and conducting a genome-wide association study (GWAS) involving brain tissue from nearly 700 participants postmortem, as part of the Rush Memory and Aging Project and the Religious Orders Study.
- - Researchers identified the strongest genetic association with brain aging at SNP rs4244620, which also showed significant ties to cognitive decline and neurodegenerative signs, using additional data from nearly 1,700 subjects.
- - The findings highlighted specific proteins, like TMEM106B and THSD7A, that correlate with Alzheimer’s disease pathology and cognitive decline, reinforcing their potential roles in the mechanisms of brain aging.
Introduction: Dietary patterns are associated with dementia risk, but the underlying molecular mechanisms are largely unknown.
Methods: We used RNA sequencing data from post mortem prefrontal cortex tissue and annual cognitive evaluations from 1204 participants in the Religious Orders Study and Memory and Aging Project. We identified a transcriptomic profile correlated with the MIND diet (Mediterranean-Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay) among 482 individuals who completed ante mortem food frequency questionnaires; and examined its associations with cognitive health in the remaining 722 participants.
Background: Midlife residential exposure to greenspace may slow cognitive decline by increasing opportunities for physical activity and social connection, restoring attention, or reducing stress or adverse environmental exposures. However, prospective studies on the association between greenness and cognitive decline are sparse.
Objective: We investigated the prospective association between greenness at midlife and cognitive decline later in life.
Objective: Optimism and purpose in life are associated with improved health outcomes. More information is needed on biological mechanisms, including immunosenescence. We investigated if psychological well-being is associated with healthier immunosenescence-related measures including naïve and terminally differentiated CD4 and CD8 T cell percentages, CD4:CD8, and cytomegalovirus (CMV) IgG response.
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