Publications by authors named "F Gravey"
Specific determinants associated with Uropathogenic (UPEC) causing recurrent cystitis are still poorly characterized. Using strains from a previous clinical study (Vitale study, clinicaltrials.gov, identifier NCT02292160) the aims of this study were (i) to describe genomic and phenotypic traits associated with recurrence using a large collection of recurrent and paired sporadic UPEC isolates and (ii) to explore within-host genomic adaptation associated with recurrence using series of 2 to 5 sequential UPEC isolates.
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- The study investigates how bacteria adapt to patients over long hospital stays, focusing on antimicrobial resistance and metabolic changes in the gut during intensive care unit (ICU) admissions.
- Weekly rectal swabs from ICU patients were analyzed to track the evolution of enteric bacterial populations, revealing that only a small number of patients harbored distinct strains.
- Key findings included a persistent strain that exhibited significant changes in drug resistance, highlighting the impact of genetic mutations on bacterial behavior and patient treatment challenges.
The aim of this study was to evaluate the proportion of resistance to a temocillin, tigecycline, ciprofloxacin, and chloramphenicol phenotype called t2c2 that resulted from mutations within the locus among extended-spectrum β-lactamases (ESBL-E) isolated in three intensive care units for 3 years in a French university hospital. Two parallel approaches were performed on all 443 ESBL-E included: (i) the minimal inhibitory concentrations of temocillin, tigecycline, ciprofloxacin, and chloramphenicol were determined and (ii) the genomes obtained from the Illumina sequencing platform were analyzed to determine multilocus sequence types, resistomes, and diversity of several -associated genes including operon. Among the 443 ESBL-E strains included, isolates of ( = 194), ( = 122), and complex () ( = 127) were found.
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- In places like Cambodia, where sanitation is poor, bacteria can easily spread between humans and animals, worsening the problem of antibiotic resistance.
- The study found similar patterns of antibiotic resistance in humans and animals in Cambodia, highlighting the need for better control at the human-animal interface to combat this issue effectively, particularly in lower and middle-income countries.