How to manage hypersensitivity reactions to biological agents?

Biological agents induce cutaneous adverse drug reactions (CADR) different from those observed with xenobiotics. Type alpha is the cytokine release syndrome, type beta are hypersensitivity reactions and type gamma is a cytokine imbalance syndrome. Infusion-reactions, anaphylactoid reactions occur with various biological agents administered intravenously.

Arterial stiffness predicts severe progression in systemic sclerosis: the ERAMS study.

Objective: The ERAMS study addressed the value of arterial stiffness in predicting the severity of systemic sclerosis.

Methods: ERAMS was a prospective multicentre cohort study including patients with definite systemic sclerosis. Arterial stiffness was measured by the standardized non-invasive QKd 100-60 method.

Clinical variants of the preprotuberant stage of dermatofibrosarcoma protuberans.

Background: Some cases of dermatofibrosarcoma protuberans (DFSP) do not protrude above the skin.

Objectives: To assess the prevalence of these DFSPs and further to describe their presentation and course.

Methods: One hundred and forty-three patients were retrospectively collected.