Publications by authors named "F Gossink"
Article Synopsis
- Patients with phenocopy syndrome of bvFTD (phFTD) exhibit behavioral symptoms similar to those with behavioral variant frontotemporal dementia (bvFTD) but lack neuroimaging abnormalities and progression, complicating accurate diagnosis.* -
- A study involving 128 patients aimed to differentiate phFTD from bvFTD by assessing symptoms reported by clinicians, patients, and caregivers; results showed that phFTD patients generally had better facial emotion recognition but reported more depressive symptoms.* -
- The study concluded that social cognition tests, particularly facial emotion recognition, are the most effective in distinguishing phFTD from bvFTD, and highlighted the need for further research on phFTD's causes and the role of caregivers
Objectives: Distinguishing sporadic behavioral variant of frontotemporal dementia (bvFTD) from late-onset primary psychiatric disorders (PPD) remains challenging with the lack of robust biomarkers. An early bvFTD misdiagnosis in PPD cases and vice-versa is common. Little is known about diagnostic (in)stability over longer period of time.
View Article and Find Full Text PDFBecause the behavioral variant of frontotemporal dementia (bvFTD) shows major clinical overlap with primary psychiatric disorders (PPD) that affect similar neuroanatomical circuits, a common genetic vulnerability between FTD and PPD was hypothesized. We studied whether PPD are more prevalent in families of patients with sporadic frontotemporal dementia compared with healthy controls (HC), subjects with Alzheimer's disease (AD), and individuals with bipolar disorder (BD). In this case-control study performed between January 2013 and February 2019, we investigated the first-degree family history concerning depression, psychosis (including schizophrenia), BD, and autism spectrum disorder for 73 bvFTD patients, 153 patients with BD, 108 patients with AD, and 101 HC with a semistructured questionnaire (QFTD-NL 1.
View Article and Find Full Text PDFBackground: The behavioural variant of frontotemporal dementia (bvFTD) strongly resembles primary psychiatric disorders. Furthermore, a bvFTD mimic may occur, without neurodegenerative aetiology.
Aim: To offer psychiatrist clinical tools for making or ruling out a bvFTD diagnosis.
Background: Behavioral variant frontotemporal dementia (bvFTD) is generally considered a young-onset dementia, although age at onset is highly variable. While several studies indicate clinical differences regarding age at onset, no biomarker validated cohort studies with updated clinical criteria have been performed.
Objective: We aimed to examine behavior, cognition, and mortality over the full age spectrum in a cohort of bvFTD patients with neuroimaging, genetic, or histopathological confirmation and exclusion of positive Alzheimer's disease biomarkers or severe cerebrovascular damage.