Assessment of neurological injury due to circulatory arrest during profound hypothermia. An experimental study in vertebrates.

To investigate brain changes in induced deep core hypothermia (15 degrees C) with circulatory arrest, five groups of neonatal pigs were subjected to cardiopulmonary bypass (CPB), with circulatory arrest (CA) periods varying from 70-120 min. The parameters analysed were: 1. Histology and electron microscopy of the brain six hours post-CPB, 2.

Early postoperative myocardial morbidity in patients with coronary artery disease undergoing major non-cardiac surgery: correlation with perioperative ischaemia.

As a part of a study assessing early postoperative myocardial morbidity in 50 patients with active coronary artery disease undergoing major non-cardiac surgery, the ECG was monitored continuously for 24 hr after the onset of anaesthesia, using a frequency modulated (FM) Holter monitor. Concurrent automated blood pressure and pulse were measured non-invasively at three-minute intervals during anaesthesia and subsequently at five-minute intervals. Thirty patients were monitored with two-site ECG recordings, from modified V1 and V5 (Group A).

Postoperative myocardial damage in patients with coronary artery disease undergoing major non cardiac surgery.

A prospective study was carried out in a group of 50 patients with coronary artery disease, presenting for major non-cardiac surgery, to investigate the timing and incidence of further perioperative myocardial damage. A standardised anaesthetic was used. A standard 12-lead ECG was taken immediately before surgery and at 24, 48, and 72 hr after the start of anaesthesia.