Publications by authors named "F Gomez-Garcia"
Concerns regarding the systematic review and editorial on oral dutasteride for frontal fibrosing alopecia.
J Eur Acad Dermatol Venereol
January 2025
Article Synopsis
- - Alopecia areata (AA) is an autoimmune condition that leads to hair loss, influenced by genetic and environmental factors, with recent studies suggesting that scalp microbiota may affect its progression through inflammatory responses.
- - A study with 24 participants analyzed the scalp microbiomes of those with varying severities of AA and healthy individuals, finding significant differences in microbial communities and their correlation with inflammation and AA severity.
- - Results showed that patients with severe AA had more pro-inflammatory bacteria, while those with milder forms had beneficial bacteria, indicating that scalp microbiota might be linked to AA inflammation, though further research is needed to understand the exact relationship.
Recently, it has been recognized that changes in sagittal alignment and spinopelvic mobility due to alterations of the lumbosacral spine can influence the dislocation of a hip replacement. The biggest difficulties for this problem are: a) the bibliography related to this topic has been written in English and there is confusion in its terminology; b) there is no consensus on what parameters should be used to identify, measure, and estimate the risks of dislocation occurring; c) the basic concepts that interrelate spinal disorders and prosthetic dislocation are not clearly understood; and d) spine and hip surgeons pursue different goals. The objective of this narrative review is to overcome the aforementioned difficulties by using a strategy to answer some questions: Is hip dislocation really a problem? What is the interrelationship between alterations in the pelvic spinal balance and the dislocation of a prosthesis? How is sagittal balance and lumbosacral mobility defined and how can their alterations be measured? What are their compensatory mechanisms to achieve a good functioning and how these mechanisms can be used to correctly orient the acetabulum? To document this review, we consulted the databases of PubMed, Scopus, SciELO and Google Scholar with the keywords: Spinopelvic, Total Hip Arthroplasty, Hip Dislocation, Spine-Pelvis-hip Arthroplasty.
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- The study by Chen et al. introduces base editing as a groundbreaking genetic engineering tool used in a rat model to treat primary hyperoxaluria type 1, a liver-originating disease that primarily impacts the kidneys.
- The commentary offers insights into the gene-editing technology utilized and evaluates the results presented by the authors.
- It also discusses potential future uses of this technology in medical treatment.
Introduction: This scoping review explores the effectiveness of IL-1 pathway inhibitors in managing PSTPIP1-associated inflammatory diseases (PAID). These diseases are marked by abnormal IL-1 pathway activation due to genetic mutations.
Methods: Our methodology adhered to a pre-published protocol and involved a thorough search of MEDLINE and EMBASE databases up to February 2022, following the Joanna Briggs Institute Reviewer's Manual and the PRISMA Extension for Scoping Reviews.