A pioneering longterm experiment on mesophotic macrofouling communities in the North Atlantic.

The mesophotic zone represents one of our planet's largest and least explored biomes. An increasing number of studies evidence the importance of macrofouling species in marine ecosystems, but information on these communities and the factors influencing their structures at mesophotic depths remain poor. This lack of understanding limits our ability to predict anthropogenic impacts or conduct restoration operations in the mesophotic and the lower boundary of the euphotic zones.

Evaluating fish foraging behaviour on non-indigenous Asparagopsis taxiformis using a remote video foraging system.

The proliferation of pest and invasive marine macroalgae threatens coastal ecosystems, with biotic interactions, including direct effects such as grazing and indirect effects such as the trophic cascades, where one species indirectly affects another through its interactions with a third species, play a critical role in determining the resistance of local communities to these invasions. This study examines the foraging behaviour and preference of native fish communities toward native (Halopteris scoparia, Sargassum vulgare) and non-indigenous (Asparagopsis taxiformis) macroalgae using the Remote Video Foraging System (RVFS). Fifty-four weedpops were deployed across three locations to present these macroalgae, while associated epifaunal assemblages were also collected.

An allosteric inhibitor of the PhoQ histidine kinase with therapeutic potential against Salmonella infection.

Background: The upsurge of antimicrobial resistance demands innovative strategies to fight bacterial infections. With traditional antibiotics becoming less effective, anti-virulence agents or pathoblockers, arise as an alternative approach that seeks to disarm pathogens without affecting their viability, thereby reducing selective pressure for the emergence of resistance mechanisms.

Objectives: To elucidate the mechanism of action of compound N'-(thiophen-2-ylmethylene)benzohydrazide (A16B1), a potent synthetic hydrazone inhibitor against the Salmonella PhoP/PhoQ system, essential for virulence.

Insertion sequence IS6770 modulates potassium symporter kup transcription in Enterococcus faecalis JH2-2 under low pH conditions.

Enterococcus faecalis is a phylogenetically and industrially relevant microorganism associated with Lactic Acid Bacteria. Some strains of this bacterium are employed as probiotics in commercial applications, while others serve as the principal component in starter cultures for artisanal regional cheese production. However, over the last decade, this species has emerged as an opportunistic multiresistant pathogen, raising concerns about its impact on human health.

Enhancing colistin efficacy against Salmonella infections with a quinazoline-based dual therapeutic strategy.

Colistin remains one of the last-resort therapies for combating infections caused by multidrug-resistant (MDR) Enterobacterales, despite its adverse nephro- and neuro-toxic effects. This study elucidates the mechanism of action of a non-antibiotic 4-anilinoquinazoline-based compound that synergistically enhances the effectiveness of colistin against Salmonella enterica. The quinazoline sensitizes Salmonella by deactivating intrinsic, mutational, and transferable resistance mechanisms that enable Salmonella to counteract the antibiotic impact colistin, together with an induced disruption to the electrochemical balance of the bacterial membrane.