Publications by authors named "F Giorgino"
Aims: To evaluate glucose metrics, device satisfaction and diabetes impact in adults with type 1 diabetes using different treatment modalities in a real-life setting in Italy.
Methods: This was a multicentre, nationwide, cross-sectional study. Candidates were consecutively evaluated for eligibility during their routine medical visit at the diabetes centre.
Efficacy and Safety of Different Hybrid Closed Loop Systems for Automated Insulin Delivery in People With Type 1 Diabetes: A Systematic Review and Network Meta-Analysis.
Diabetes Metab Res Rev
September 2024
Aims: To compare the efficacy and safety of different hybrid closed loop (HCL) systems in people with diabetes through a network meta-analysis.
Methods: We searched MEDLINE, EMBASE, CENTRAL and PubMed for randomised clinical trials (RCTs) enrolling children, adolescents and/or adults with type 1 or type 2 diabetes, evaluating Minimed 670G, Minimed 780G, Control-IQ, CamAPS Fx, DBLG-1, DBLHU, and Omnipod 5 HCL systems against other types of insulin therapy, and reporting time in target range (TIR) as outcome.
Results: A total of 28 RCTs, all enrolling people with type 1 diabetes, were included.
Article Synopsis
- Carney complex (CNC) is a rare disease caused by changes in the PRKAR1A gene, leading to skin changes and various tumors.
- A 41-year-old woman with a complicated medical history faced challenges when doctors tried to find out what was wrong with her, which included multiple tumors and strokes.
- Genetic testing finally confirmed she had CNC, showing how important teamwork among doctors is for diagnosing and treating rare health issues.
Purpose: Randomized controlled trials with tirzepatide (TZP) displayed unprecedented glucose and body weight lowering efficacy in individuals with type 2 diabetes and/or obesity and a safety profile similar to that of glucagon-like peptide-1 receptor agonists (GLP-1RA), mainly characterized by gastrointestinal (GI) adverse events (AE). Concerns on diabetic retinopathy, pancreato-biliary disorders, and medullary thyroid cancer were also addressed. We aimed to investigate whether the same safety issues emerged from the FDA Adverse Event Reporting System (FAERS) post-marketing surveillance database.
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- PCOS is a common hormonal disorder with diagnostic and management complexities, prompting a study on European endocrinologists' understanding of it.
- An online survey of 505 endocrinologists revealed that 85% use the Rotterdam criteria for diagnosis, with most patient referrals occurring between ages 20 and 40.
- The findings highlight the importance of metabolic profiling and lifestyle changes in managing PCOS, along with consensus on using treatments like metformin and oral contraceptives.