Publications by authors named "F Gianfrancesco"
Is early continence recovery related to the length of spared urethra? A prospective multicenter study comparing preoperative MRI and histologic specimen measurements after robotic radical prostatectomy.
Eur J Surg Oncol
June 2024
Article Synopsis
- Urinary incontinence (UI) is a frequent issue following radical prostatectomy, with this study investigating the relationship between the length of the preserved urethra and urinary continence within the first 90 days post-surgery.
- The study involved 190 prostate cancer patients who underwent robotic surgery, measuring pre-operative urethral length via MRI and correlating it with post-operative outcomes categorized into two groups: those with UI and those without.
- Results showed that a higher percentage of preserved urethra significantly correlates with quicker recovery of urinary continence, supporting the importance of preserving urethral length during surgery.
A mutation in the ZNF687 gene that is responsible for the severe form of Paget's disease of bone causes severely altered bone remodeling and promotes hepatocellular carcinoma onset in a knock-in mouse model.
Bone Res
March 2023
Paget's disease (PDB) is a late-onset bone remodeling disorder with a broad spectrum of symptoms and complications. One of the most aggressive forms is caused by the P937R mutation in the ZNF687 gene. Although the genetic involvement of ZNF687 in PDB has been extensively studied, the molecular mechanisms underlying this association remain unclear.
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- - Profilin 1, a protein encoded by PFN1, has a potential tumor-suppressive function in certain cancers, but its exact role in tumor development remains unclear.
- - Research shows that inactivating Profilin 1 leads to severe mitotic issues like anaphase bridges and improper chromosome alignment, which can contribute to genomic instability in cancer cells.
- - The study reveals that Profilin 1 helps in proper cell division by supplying actin filaments during cytokinesis, and its absence is linked to structural anomalies in cells and tumor progression.
Osteoclasts are highly specialized cells of the bone, with a unique apparatus responsible for resorption in the process of bone remodeling. They are derived from differentiation and fusion of hematopoietic precursors, committed to form mature osteoclasts in response to finely regulated stimuli produced by bone marrow-derived cells belonging to the stromal lineage. Despite a highly specific function confined to bone degradation, emerging evidence supports their relevant implication in bone tumors and metastases.
View Article and Find Full Text PDFBackground: Parkinson's disease (PD) is a neurodegenerative movement disorder affecting 1-5% of the general population for which neither effective cure nor early diagnostic tools are available that could tackle the pathology in the early phase. Here we report a multi-stage procedure to identify candidate genes likely involved in the etiopathogenesis of PD.
Methods: The study includes a discovery stage based on the analysis of whole exome data from 26 dominant late onset PD families, a validation analysis performed on 1542 independent PD patients and 706 controls from different cohorts and the assessment of polygenic variants load in the Italian cohort (394 unrelated patients and 203 controls).