Role of NLRP3 Inflammasome in Chronic Pain and Alzheimer's Disease-A Review.

The coexistence of Alzheimer's disease (AD) and chronic pain (CP) in the elderly population has been extensively documented, and a growing body of evidence supports the potential interconnections between these two conditions. This comprehensive review explores the mechanisms by which CP may contribute to the development and progression of AD, with a particular focus on neuroinflammatory pathways and the role of microglia, as well as the activation of the NLR family pyrin domain containing 3 (NLRP3) inflammasome. The review proposes that prolonged pain processing in critical brain regions can dysregulate the activity of the NLRP3 inflammasome within microglia, leading to the overproduction of pro-inflammatory cytokines and excessive oxidative stress in these regions.

Rapid mimetic micro-contact nano-fluorosensor based on molecularly imprinted polymers for the detection of amygdalin in biological matrices.

In this study, a mimetic fluorescence nanosensor based on a molecularly imprinted polymer was designed for the detection of amygdalin (AMG). Its characteristics and functional performance were investigated and recorded using ATR-FTIR, AFM and porosity tests. This designed sensor is considered superior to other reported techniques due to its low material consumption during both manufacturing and operation as well as its low cost and desirable performance characteristics, such as short response time, high stability and an appropriate detection limit.

Healthcare utilization among people with disabilities in Iran: what predictors are associated with medical visits?

Background: Ensuring equitable access to healthcare services for individuals with disabilities poses a significant challenge for healthcare systems. This research aimed to explore the factors affecting medical visits among this population.

Method: This cross-sectional study in Iran involved data from 766 adults with disabilities aged 18 and older.

Coffee consumption and adverse cardiovascular events in patients with atrial fibrillation.

Background: There is some evidence of reduced major cardiovascular event (MACE) rates associated with moderate coffee consumption in the general population. However, there is concern about the potential risks of coffee consumption in patients with atrial fibrillation (AF). Therefore, we aimed to investigate the association between coffee consumption and MACE in AF patients.

Association of serum levels of inflammation and oxidative stress markers with cognitive outcomes in multiple sclerosis; a systematic review.

Background: Multiple sclerosis (MS) is an immune-mediated disease with cognitive impairment being a crucial manifestation. Oxidative stress and inflammation play significant roles in the disease's pathogenesis. This systematic review explores the association between inflammation and oxidative stress markers, with cognitive outcomes in MS patients.