Publications by authors named "F Genovese"
Cinnamic acid (CA) has many beneficial effects on human health. However, its poor water solubility (0.23 g/L, at 25 °C) is responsible for its poor bioavailability.
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- Nonsense mutations lead to a stop signal in protein production, resulting in non-functional proteins and contributing to diseases like cystic fibrosis (CF).
- This research explores the potential of NV848, a drug designed to promote the continuation of protein synthesis, to enhance CFTR protein expression in a mouse model with a specific CF-causing mutation.
- The study evaluates the drug's stability, distribution in the body, and effectiveness in restoring CFTR protein in mice, suggesting NV848 could be a valuable treatment for CF patients with nonsense mutations.
Background And Purpose: Fremanezumab, a monoclonal antibody targeting the calcitonin gene-related peptide for migraine prevention, is available in monthly (225 mg) and quarterly (675 mg) doses. Previous studies showed efficacy and safety for both regimens, but a real-life comparison is lacking. This study aimed to compare the effectiveness and safety of monthly and quarterly fremanezumab in a real-life setting.
View Article and Find Full Text PDF: Recent advances in cancer diagnosis and treatment have significantly improved survival rates among women of reproductive age facing cancer. However, the potential iatrogenic loss of fertility caused by chemotherapeutic agents underscores the need to understand and predict chemotherapy-induced ovarian damage. This study addresses this gap by systematically reviewing the literature to investigate genetic markers associated with chemotherapy-induced ovarian failure (CIOF).
View Article and Find Full Text PDFRecent efforts in the study of vector-borne parasitic diseases (VBPDs) have emphasized an increased consideration for preventing drug resistance and promoting the environmental safety of drugs, from the beginning of the drug discovery pipeline. The intensive use of the few available antileishmanial drugs has led to the spreading of hyper-resistant strains, resulting in a chronic burden of the disease. In the present work, we have investigated the biochemical mechanisms of resistance to antimonials, paromomycin, and miltefosine in three drug-resistant parasitic strains from human clinical isolates, using a whole-cell mass spectrometry proteomics approach.
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