Publications by authors named "F Garcia-Dolores"
Article Synopsis
- Valproic acid (VPA) is associated with liver damage, but a new compound derived from it, HO-AAVPA, shows improved antiproliferative effects against cancer.
- A study on HO-AAVPA involved testing its effects on liver toxicity in rats and mice, with results indicating it has a higher median lethal dose (LD) than 2000 mg/kg and does not cause liver injury at therapeutic doses.
- Compared to VPA, HO-AAVPA led to fewer liver lesions and less disruption to liver enzyme levels, suggesting it could be a safer alternative for cancer treatment without the risk of hepatotoxicity.
