The Prevalence of Gingival Recession According to the Cairo Classification in a Population from the North of Portugal.

Gingival recession (GR) has a multifactorial etiology, resulting from the interaction of various factors. It affects aesthetics and comfort, and has negative consequences for quality of life. The main objective of this study is to investigate the prevalence of gingival recession in a sample of the population in northern Portugal, according to the classification system proposed by Cairo.

Toward the development of an ML-driven decision support system for wastewater treatment: A bacterial inactivation prediction approach in solar photochemical processes.

The design of efficient bacterial inactivation treatment in wastewater is challenging due to its numerous parameters and the complex composition of wastewater. Although solar photochemical processes (PCPs) provide energy-saving benefits, a balance must be maintained between bacterial inactivation efficiency and experimental costs. Predictive decision tools for bacterial inactivation under various conditions would significantly contribute to optimizing PCP design resources.

Sustainable assessment of ultrasound-assisted extraction of anthocyanins with bio-based solvents for upgrading grape pomace Cabernet Sauvignon derived from a winemaking process.

This work assessed the efficiency and sustainability of ultrasound-assisted extraction (UAE) of anthocyanins from grape pomace using bio-based solvents: Ethanol, Isopropanol, Propylene-glycol, and Ethylene-glycol at different concentrations (50 and 100 % v/v) and temperatures (25 °C and 50 °C). Higher ultrasonic intensities (UI) were obtained at 50 °C and 50 % v/v by decreasing solvents viscosities. Under these conditions, anthocyanin extractions were performed with different combinations of solvent to liquid ratio (SLR) at 1:10 and 1:50 g/mL, and UI (3.

Molecular Modeling of Vasodilatory Activity: Unveiling Novel Candidates Through Density Functional Theory, QSAR, and Molecular Dynamics.

Cardiovascular diseases (CVD) pose a significant global health challenge, requiring innovative therapeutic strategies. Vasodilators, which are central to vasodilation and blood pressure reduction, play a crucial role in cardiovascular treatment. This study integrates quantitative structure- (QSAR) modeling and molecular dynamics (MD) simulations to predict the biological activity and interactions of vasodilatory compounds with the aim to repurpose drugs already known and estimateing their potential use as vasodilators.

Influence of electroporation parameters on the reaction and transport mechanisms in electro-chemotherapeutic treatments using Boolean modeling and the Method of Fundamental Solutions.

The systemic administration of chemotherapeutic drugs involves some reaction and transport mechanisms (RTMs), including perfusion along the blood vessels, extravasation, lymphatic drainage, interstitial and transmembrane transport, and protein association and dissociation, among others. When tissue is subjected to the controlled application of electric pulses (electroporation), the vessel wall and cell membrane are permeabilized, capillaries are vasoconstricted and tissue porosity is modified, affecting the RTMs during electro-chemotherapeutic treatments. This study is a theoretical investigation about the influence of the electric field magnitude (E), number of electroporation treatments (N) and duration of each electroporation protocol (T) on the presence, interaction and rates of the RTMs using in-house computational tools.