Scientific truth: an endangered species.

Academic research and selection panels need to deal with the problem of predatory journals as these are slowly but inevitably poisoning the scientific record. [Image: see text]

Genetic information and insurance.

The use of genetic data for diagnosis increases the risk of genetic discrimination by insurance companies and could hinder progress in medicine. [Image: see text]

Unintended consequences of changes to Open Access and the Impact Factor.

The move to Open Access publishing and the diminishing weight of the Impact Factor has unintended and even negative consequences. [Image: see text]

Clinical trials and tribulations.

We need better post-approval monitoring and reporting to assess the efficiency of new cancer therapies in the real world beyond clinical trials. [Image: see text]

Early Resveratrol Treatment Mitigates Joint Degeneration and Dampens Pain in a Mouse Model of Pseudoachondroplasia (PSACH).

Pseudoachondroplasia (PSACH), a severe dwarfing condition associated with early-onset joint degeneration and lifelong joint pain, is caused by mutations in cartilage oligomeric matrix protein (COMP). The mechanisms underlying the mutant-COMP pathology have been defined using the MT-COMP mouse model of PSACH that has the common D469del mutation. Mutant-COMP protein does not fold properly, and it is retained in the rough endoplasmic reticulum (rER) of chondrocytes rather than being exported to the extracellular matrix (ECM), driving ER stress that stimulates oxidative stress and inflammation, driving a self-perpetuating cycle.